Over the past 25 years, CIRION has developed a strong expertise in the field of virology. Our laboratories can provide BSL-2 services such as cell culture and infectivity capability. Many common viruses can be detected and quantified with our standard assays:
Immunogenicity Assessment for the Humoral Antibody Response
Specific antibody measurement:
• Ligand-binding assay
- ELISA, ECLIA, inhibition ELISA: qualitative and quantitative/titer;
- Antibody isotyping assay.
Functional antibody measurement:
• Hemagglutination inhibition assay
• Cell-based assay
- Viral-neutralization assay;
- Plaque inhibition assay.
Immunogenicity Assessment for Cell-Mediated Immunity
Measurement of immune cells' response upon exposure to specific antigens:
• Flow cytometry from whole blood or from PBMC.
Efficacy Assessment
Measurement of antigen or other markers:
• Ligand-binding : biomarkers with multiplexing capability;
• Molecular assays : qPCR for viral load quantification and subtyping.
Exposure and Safety Assessment
Measurement of infectivity and biodistribution
• Cell-based assays and molecular assays
These are only a few examples of CIRION's service offering. For more information, or a special request, please contact us toll free at 1-866-688-2474 or by e-mail at businessdevelopment@cirion.com.